Research Study – BDMC-A: A Chemopreventive Agent

Cancer is a widespread disease and major cause of deaths worldwide. It develops when certain cells continue to divide uncontrollably forming tumours and invading other tissues.

Curcumin is a polyphenolic compound obtained from turmeric which gives it a yellow colour and therapeutic properties. It is a very effective anti-cancer agent.

Its ability to prevent and treat cancer without producing significant side effects is well known. A large number of research studies have been conducted to establish this fact.

Anti-cancer properties of BDMC-A

In a recent study published in the journal Biomedicine and Pharmacotherapy, scientists have explored the therapeutic effects of a curcumin analog, BDMC-A in controlling angiogenesis and spreading of cancer cells suggesting that its anti-cancer properties surpass those of curcumin itself.

The research included in vitro and in silico studies on MCF-7 cells which are breast cancer cells.

The activity of both curcumin and an analog of curcumin i.e. BDMC-A on cancer cell invasion and metastasis were studied and compared.

BDMC-A inhibits angiogenesis, a process by which new blood vessels and lymph vessels are formed. Angiogenesis promotes cancer cell growth and proliferation by supplying adequate amounts of oxygen and nutrients to them.

It also helps in prevention of metastasis, a process by which cancer cells spread to other parts of the body and invade new cells.

This spreading is facilitated by blood and lymph vessels.

The scientists in this study investigated the various mechanisms by which BDMC-A produces its inhibitory effect on angiogenesis and metastasis.

They found that it regulates the activity of inflammatory pathways like NF-KB , TGF-beta , TNF-alpha , IL-1 beta and C-SRC all of which play important roles in cancer development and progression.

It down-regulates the levels of c-REL , MMP-9 , VEGF , IL-8 and cycloxygenase 2 cytokine thereby preventing cancer cell proliferation and metastasis due to angiogenesis.

On comparing the results produced by BDMC-A with those produced by curcumin, they found that BDMC-A was significantly better in controlling the disease and inhibiting its biomarkers than curcumin.

They believe that this was probably because of the hydroxyl (-OH) group that was present on the ortho position of BDMC-A structure.

Conclusion

Cancer is a widespread disease and its immediate prevention and control are needed.

Various chemopreventive agents and therapies are available but they are not always effective and produce a variety of side effects.

The anti-cancer properties of curcumin are well known but Scientists have found that an analogue of curcumin BDMC-A is even better than curcumin in controlling cancer.

It prevents cancer invasion, angiogenesis and it’s subsequent spreading to different organs by regulation of nf-kb and other inflammatory pathways and inhibition of the expression of cancer-promoting proteins and cytokines.

The –OH group on its ortho position is responsible for its enhanced activity.

This suggests that BDMC-A can help in producing novel therapies for cancer treatment.

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