If you follow this blog regularly, it is an absolute no brainer as to what curcumin really is?! But the magic of turmeric is slowly spreading its roots and contributing to health of various individuals around the world.
And to answer this you need to know what curcumin is in the first place and then you would know which of the two – turmeric or curcumin, suits your needs?
What is curcumin?
A simple definition of curcumin would be that it is one of the bioactive ingredients found in turmeric. Turmeric is a root like herb/spice that belongs to the ginger family. (Read Introduction to Turmeric)
The main active constituents of turmeric can be divided in two groups: curcuminoids and turmeric oil. Turmeric contains a wide variety of phytochemicals, including curcumin, , zingiberene, curcumenol, curcumol, tetrahydrocurcumin, , turmerin, turmerones, and turmeronols.
Curcuminoids are a group of compounds that offer yellow orange color to turmeric. Naturally the 3 main curcuminoids are curcumin, bisdemethoxycurcumin and demethoxycurcumin.
Curcuminoids are natural antioxidants and responsible for turmeric’s hue. Curcumin is one such curcuminoid. (Read Is Curcumin different from Curcuminoids?)
Chemical structure of curcumin
Now curcumin (also known as Curcumin I) was first isolated in 1815 by Vogel and Pelletier as the ‘yellow coloring matter’ from turmeric. However this was a mixture of resin and turmeric oil. Vogel Jr. obtained purified curcumin in 1842 but did not report its formula.
It was later obtained in crystalline form in 1870. Lampe et.al. identified the structure of curcumin in 1910 as diferuloylmethane or 1,6-heptadiene-3,5-dione-1,7-bis (4-hydroxy-3-methoxyphenyl)-(1E, 6E). Lampe et.al later documented the synthesis in 1913.
In 1953, Srinivasan identified and separated components of curcumin mixture or curcuminoids naturally present in turmeric. So it is the mixture of curcumin that offers yellow pigment to turmeric.
As mentioned prior, this mixture contains curcumin (Curcumin I), demethoxycurcumin (curcumin II), bisdemethoxycurcumin (curcumin III).
The molecular formula of curcumin is C21H20O6 and has a molecular weight of 368.385 g/mol. It has a melting point of 183 degree Celsius. Curcumin is insoluble in water and ether, soluble in alcohol, acetic acid, Dimethylsulfoxide and acetone.
Curcumin has a brilliant yellow color under acidic to neutral conditions (pH 2.5 to 7) and turns red in color at a pH above 7 or alkaline conditions.
First Scientific Discoveries and History of Curcumin’s use
The first use of ‘Curcuma’ (what turmeric was known then) was reported in 1748.
The first article suggesting the use of curcumin in humans was published in 1937 by Oppenheimer.
In this study curcumin was used to treat gallbladder diseases. Rapid emptying of gallbladder was seen and as per the report the author treated 67 patients of cholecystitis (inflammatory gall bladder disease).
Both oral administration and intravenous injection deliver good results and no side effects were seen. All expect 1 patient was cured based on the observations conducted over a period of 3 months to more than 3 years.
Later in 1949 and 1972 the antibacterial and blood sugar lowering effect of curcumin was documented. Also its cholesterol lowering , antioxidant and anti-inflammatory properties were documented in 1970s.
In 1980s Kuttan et.al documented the anti-cancer properties of turmeric and curcumin. As of now in 2017 over 9000 studies on curcumin are recorded in Pubmed, database of National Institutes of Health.
How much curcumin does turmeric have?
Having learnt about curcumin’s structure and discovery, you now have understood that curcumin is one of the bioactives or phytochemicals found in turmeric.
Curcuminoids constitutes around 2-6% of turmeric and it can be found in various species of Curcuma family. We are focusing on yellow turmeric or Curcuma longa. The mixture contains 80% curcumin, 18% demethoxycurcumin, and 2% bisdemethoxycurcumin.
It is true that whole turmeric or raw turmeric has a low concentration of curcumin but it has many other beneficial compounds that give the status of a miracle herb.
Also some researchers state that natural composition of curcumin in turmeric- that is its combination with other curcuminoids and turmeric oils aids in absorption of curcumin and potentiates its therapeutic effect.
10 Awesome Health Benefits of Curcumin
There a number of studies that have proven the benefits of curcumin in various health conditions. Here are the top 10 Health benefits of curcumin.
1.Its anti-inflammatory property can benefit in any inflammatory disorder
Curcumin is a natural anti-inflammatory agent. It acts upon and regulates multiple biochemical targets to reduce inflammation.
Unlike the regular NSAIDs which act on a particular inflammatory enzyme, curcumin acts on both COX and LOX enzymes in order to control inflammation and does not cause any gastric side effects.
This property benefits in various inflammatory disorders like arthritis, IBD, dermatitis, uveitis, thyroiditis etc.
What does this mean?
Curcumin has natural anti-inflammatory activity that is comparable to regular non steroidal anti-inflammatory property and benefits in various inflammatory disorders.
2.Curcumin’s antioxidant power improves natural antioxidant defense of the body
Curcumin and curcuminoids are natural plant based antioxidants. Curcumin raises the antioxidant enzymes in the body that help curb the oxidative stress- imbalance between prooxidant and antioxidant properties.
In fact curcumin is 10 times more active as an antioxidant than vitamin E. The structure of curcumin is greatly responsible for its antioxidant properties.
This antioxidant property of curcumin is beneficial in treating oxidative stress like conditions in diabetes, Alzheimer’s , Parkinsons’ , heavy metal toxicity, thalassemia etc.
What does this mean?
Curcumin is a natural antioxidant that helps increase antioxidant enzymes levels and indirectly alleviates symptoms of diseases involving oxidative stress.
3.It protects stomach health
Curcumin has gastroprotective properties- it protects the stomach from various conditions.
It’s anti-microbial action helps fight stomach infection. It improves digestion and reduces bloating.
It benefits in dyspepsia and stomach ulcers. Its anti-inflammatory property soothes the digestive tract in gastritis.
It exerts anti-microbial action against H.pylori infection, one of the most common causes of acid reflux.
What does this mean?
Curcumin improves digestion and benefits stomach health protecting it from various health conditions like acid reflux, food poisoning, H.pylori infection.
4.It can benefit in autoimmune conditions
Curcumin has immunomodulatory property- it regulates immune responses. In infectious conditions, curcumin can stimulate immune responses to fight infections.
In autoimmune conditions, this property of curcumin can regulate inappropriate immune responses. This reduces inflammation or autoimmune reactions occurring in this condition.
This activity of curcumin reduces the production of proinflammatory enzymes, prevents migration of immune cells to sites of inflammation. Its immunomodulatory action may also help reduce allergy and hypersensitivity.
What does this mean?
Curcumin’s immunomodulatory action helps in autoimmune conditions like lupus, arthritis, diabetes and allergic conditions.
5.Curcumin benefits in various skin conditions
Turmeric is excellent for skin health and curcumin has also been identified as useful for skin related disorders.
Curcumin benefits in various skin disorders like psoriasis, dermatitis, acne, sunburns and also reduce skin related ageing signs.
Its skin regenerative potential helps in speeding up wound healing.
What does this mean?
Curcumin remedies various skin disorders like psoriasis, acne, sunburns dermatitis and also hastens wound healing.
6.It benefits heart and vascular health
One of the principle ways by which curcumin benefits heart health is by lowering cholesterol levels. This action is of help in conditions like atherosclerosis, hyperlipidemia, metabolic syndrome etc.
Its anti-platelet action may help in thrombosis and preventing blood clots. Curcumin helps reduce blood pressure and its cholesterol lowering property is comparable to that of statins.
It also restores heart function and facilitates cardiac repair in conditions like heart attack. Curcumin is as effective as exercise in improving vascular function in post menopausal women.
What does this mean?
Curcumin protects heart health by lowering cholesterol levels, normalizing blood pressure, exerting anti-platelet activity and improving antioxidant defences.
7.It protects and benefits brain health
Curcumin is excellent for brain health. Research shows that curcumin can improve memory, cognitive function and is also therapeutic in reducing depressive symptoms.
Curcumin also benefits in degenerative disorders like Alzheimer’s and Parkinson’s. Curcumin has anti-epileptic and anti-seizure property.
Research says that curcumin can improve learning and memory which makes it therapeutic in autism spectrum disorders. Curcumin’s anti-inflammatory and brain protective property benefits in brain injury and stroke.
What does this mean?
Curcumin helps protect brain cells as well as cognitive function and hence is therapeutic in psychiatric as well neurological disorders.
8.Curcumin is an anti-cancer and chemopreventive agent
Curcumin is a potent and natural anti-cancer agent. Around 3000+ studies and 20+ clinical trials have recorded the efficacy of curcumin in cancer and identified various mechanisms for its anti-cancer activity.
Curcumin also aids in preventing cancer and preventing spread of cancer or metastasis. It acts on as many as 30+ biochemical targets in order to induce cell death in cancer cells.
Unlike other chemotherapeutic agents, it is toxic only to cancer cells while it protects normal cells and tissues. It also helps in attenuating side effects of conventional anti-cancer therapy.
What does this mean?
Curcumin is an effective natural anti-cancer agent which acts on multiple biochemical pathways to fight cancer and also helps prevent cancer.
9.It benefits in oral health
Curcumin’s anti-inflammatory and anti-microbial action protects and improves oral health.
Research has proven that curcumin controls gum bleeding in gingivitis. It treats and reduces recurrence of oral ulcers.
Curcumin’s anti-microbial action treats oral lichen planus . Its chemopreventive action helps attenuate symptoms of oral submucosal fibrosis.
What does this mean?
Curcumin’s anti-microbial action and anti-inflammatory property helps resolve dental and oral issues.
10.Curcumin is a natural pain reliever
Curcumin is a natural analgesic. It is found to relieve pain in conditions like arthritis, sciatica and delayed onset muscles soreness.
It relieves pain by reducing inflammation and also reducing painful sensation. Studies show that certain curcumin formulations are better than conventional painkillers like diclofenac and paracetamol.
Curcumin’s painkiller action is found to be similar to opioid medications without the toxic and addictive effect.
What does this mean?
Curcumin is as effective as conventional painkillers and also serves as a non toxic painkiller.
What makes curcumin so special?
Now that’s a tricky question which researchers have been trying to answer since so many years but no one has a concrete answer yet.
Despite of improvement in technology and progress in healthcare as well the prevalence of multigenic disorders in humans has not decreased significantly. Multigenic disorders are those which involve multiple biochemical signalling pathways.
In order to treat these diseases, control or regulation of one of the biochemical pathways is insufficient. Also drugs that target only a single biochemical pathway are expensive and have adverse effects.
Natural products or bioactives found in plants target multiple biochemical pathways and are inexpensive as well as safe. Curcumin is one such compound. This ability of curcumin to affect multiple biochemical pathways is known as pleiotropicity.
Yes curcumin is a pleotropic molecule- a single molecule that can interact with various enzymes and biochemical pathways. And it is one of the components that makes turmeric an all-in-one herb (Read 20 Reasons why Turmeric is All-In-One Herb?)
K.Indira Priyadarshini in her paper Chemical and Structural Features Influencing the Biological Activity of Curcumin describes how the structure of curcumin confers to it various pharmacological properties.
The phenolic OH groups are responsible for part of the antioxidant activity while the alpha, beta-unsaturated keto-enol structure is associated with anti-tumor activity. Curcumin interacts with various biomolecules and these interactions produce reversible as well as irreversible changes in its biological function.
Based on the understanding of the structure and its related properties, researchers have developed various derivatives of curcumin with enhanced function but none of them are as potent as curcumin in terms of its multi-targeting effect or pleiotropic effect.
What is the issue with bioavailability of curcumin?
Curcumin in turmeric has poor bioavailability- it is poorly absorbed in the body and excreted from the body rapidly.
Lao et. al report that no curcumin is detected in the serum even after 1, 2 and 4 hours of administering a dose of 500-8000mg of curcumin.
The major factors that affect the bio-availability of curcumin are:
- Serum concentrations: Due to poor absorption and rapid excretion, curcumin is not maintained in the blood for long.
- Tissue distribution: Due to low absorption, curcumin does not reach target molecules effectively.
- Metabolites: Curcumin is metabolised by the liver into new compounds and research has not completely discovered the therapeutic effect of these metabolites.
- Half-life: Curcumin is rapidly excreted from the body and has an estimated half life of 6-7 hours.
So how do you deal with this bioavailability issue?! Here are a couple of ways:
- Take curcumin with piperine or bioperine: Piperine is the pungent compound of black pepper and this is known to interfere in drug metabolizing activity and serves as a natural bioenhancer. It is proven to increase absorption of curcumin by 2000%.
- Take curcumin with fats: Curcumin is fat soluble and this increases the absorption of curcumin in the gut.
Opt for specialized formulations: Various formulations of curcumin are available in the supplemental form that overcome the bioavailability issue such as Meriva, BCM-95, Theracurmin etc. Consult a health practitioner before taking curcumin supplements.
Apart from increasing the absorption, it also very important to note that curcumin also gets metabolised into various different compounds that are therapeutically active. Therefore despite of low bioavailability, it still provides health benefits.
Difference between turmeric and curcumin: Which should you take?
Oranges are a fruit and Vitamin C is its most abundant and important active constituent. Onions are a vegetable and quercetin is one of its bioactive components that are important when it comes to health.
Similarly turmeric is a herb and spice while curcumin is one of its bioactive constituents that has been proven by research to be therapeutically effective in many health conditions.
Dietary turmeric helps in various aspects such as boosting immunity, pain relief, fighting infections, improving digestion, cancer prevention etc. Apart from curcumin, turmeric has as many as 100 other bioactive compounds.
Also the natural composition of curcumin with other bioactives makes it more absorbable in the body. Therefore we recommend dietary turmeric in almost all health conditions as well daily health benefits. (Read Golden Paste, Golden Paste from fresh turmeric)
Curcumin is one bioactive ingredient that is extracted from turmeric. The most common formulation available is standardized 95% curcumin extract. This does not mean that 95% of the product is curcumin; it means 95% of the product is curcuminoids.
This product contains approximately 77% (70-80%) curcumin, 17% demethoxycurcumin and 3% bisdemethoxycurcumin. Why not 100% curcumin!?
Simply because it will not improve the potency or bioavailability in any way, but just add to the extraction costs making the product expensive. There are a variety of curcumin formulations and for further details read Is Curcumin different from Curcuminoids?
Now for certain conditions like cancer, benign tumors or major depressive disorder one may require high concentrations of curcumin which may not be possible from dietary turmeric.
The quantity of turmeric you would have to consume to get the same proportion would be higher than normal and may cause stomach upset.
Also in cases like kidney stones, gout or certain kidney diseases where potassium and oxalate intake need to be low then one may need to limit intake of turmeric as a spice and opt for curcumin supplements.
You can seek the help of a naturopath or herbalist regarding the dosage and formulation of curcumin that may suit your condition.
How safe is curcumin?
The US-FDA has approved curcumin as GRAS (generally recognized as safe). It is now incorporated in supplements, cosmetics, ointments, drinks and food items.
Researchers at University of Michigan conducted a study to assess the safety of increased dosages of curcumin in healthy individuals. Curcumin C3 complex was given to the individuals at the dose range of 500-12000mg.
34 individuals participated in the study and safety was assessed for 72 hour after administration. 24 individuals completed the study and out of that 7 experienced minimal toxicity that was unrelated to dose. These seven participants experienced diarrhea, headache, rash, and yellow stool.
Researchers at University of Leicester conducted a phase I clinical trial individuals with advanced colon cancer were given 0.45g to 3.6g of curcumin per day for 1-4 months. Nausea and diarrhea were the only adverse events noted.
Another study in pancreatic cancer patients reported abdominal pain at high doses of curcumin while in another research study patients have found high dose curcumin unacceptable due to bulky formulation size .
Curcumin is a safe and non toxic compound and the only adverse events noted till date is gastric upset and related symptoms. These can be minimized by starting with low dose of curcumin and increasing gradually.
Dosage of Curcumin For Health Benefits
Curcumin is naturally present in turmeric and turmeric powder can be included in diet. It is best taken with fats and/or black pepper to enhance the absorption. (Read Golden Paste, Golden Paste from raw turmeric)
The most common form of curcumin used in research studies is standardized 95% curcumin.
Most studies use a dose of 500mg-1000mg per day of standardized 95% curcumin. However it is best to opt for supplements with an adjuvant for absorption such as bioperine or lipid (phospholipid or phosphatidylcholine).
BCM-95, Curcumin C3 complex, Meriva, Theracurmin are few of the formulations of curcumin that are available. The dosage for each formulation differs; hence it is best to consult a doctor before taking curcumin supplements.
As mentioned previously, curcumin is safe but a few precautions need to be noted:
- Gastric side effect: High dose curcumin may cause stomach upset like symptoms. To avoid this reduce the dose of curcumin and increase gradually if needed. Also it is advisable to consume it after meals.
- Anti-platelet activity: Curcumin’s anti-platelet activity has been proven in animal studies. Therefore if you are taking a blood thinner or anticoagulant please consult a health practitioner before taking curcumin. To avoid bleeding risks, discontinue use of curcumin 2 weeks prior to any surgical procedure.
- Pregnancy and lactation: The safety of curcumin supplements in pregnancy and lactation hasn’t been confirmed. Hence it is advisable to avoid them in such case.
- Drug interaction: Curcumin interferes in drug metabolism activity and hence it is advised not to take it concomitantly with any medication. It is best to maintain 3-4 hour gap.
- Gallbladder obstruction: Research proves curcumin can cause gall bladder obstruction at low doses so if suffering from active gallbladder obstruction, avoid curcumin supplements as it may cause painful contractions.
Curcumin is one of the bioactive compounds found in the herb and spice turmeric. Curcuminoids are other compounds that are related to curcumin and found naturally in turmeric.
Since over the last decade, curcumin has been actively researched upon and over 200 pharmacological properties of curcumin have been identified.
Curcumin has limited bioavailability but despite of that it shows therapeutic activity by virtue of its metabolites.
Curcumin’s low bioavailability can be counteracted by adjuvants like bioperine.
The mechanism behind curcumin’s unique action to act on multiple biochemical targets is still not clearly identified by science but this property of curcumin makes it an attractive wholesome approach of treating and managing various health conditions.
Dietary turmeric is a great way of getting your daily dose of curcumin for health benefits.