Is Curcumin Different From Curcuminoids?

A decade ago, turmeric’s identity was limited to that of a spice and food additive. A few individuals still knew of its medicinal properties and traditional texts validated this point.

However, today turmeric is equivalent to gold in the nutraceutical industry.

And these properties of turmeric are extensively attributed to its bioactive ingredient, ‘Curcumin’. So one of the confusions that first arose was that should one take only curcumin or is turmeric better?

We have covered that in our article Should you take Turmeric or Curcumin: Which is better?.

Well science keeps throwing in new terms and facts, thus giving rise to confusion and this time it is ‘curcuminoids’. Turmeric’s active components are divided in two phases: curcuminoids and oil.

So the question is ‘Is curcumin and curcuminoids the same?’. Lets find out.

What are curcuminoids?

There are over 100 species in the Curcuma family and one thing that is characteristic of these species is the yellow orange hue. The compounds responsible for this colour are curcuminoids.

The three main curcuminoids are: curcumin, bis-demethoxycurcumin and de-methoxycurcumin. They account for 2-6% of the rhizome content (80% curcumin, 18% demethoxycurcumin and 2% bisdemethoxycurcumin). This is what their structure looks like:

curcuminoids

Adapted from: Recent advances in investigation of curcuminoids, Hideji Itokawa et al. Chinese Medicine 2008 3:11

Curcuminoids is also a term used for synthetic analogs and other derivatives of curcumin which possess key structural features.

Analogs of curcumin are also derived from other plant sources eg: 6-gingerol and their activities are very similar to curcumin. Primarily curcuminoids are potent antioxidants. In addition research proves that they also possess anti-inflammatory activity, anti-HIV and anti-cancer activity.

Some studies have implicated the use of curcuminoids in treatment of stroke, adjuvant to long term opiod therapy, Alzheimer’s disease and in case of memory deficits.

The need to prepare synthetic variations of curcuminoids is that they have poor oral bioavailability and are rapidly metabolised. Over 30 metabolites of curcuminoids have been discovered from human samples after having consumed curcuminoids.

So the idea is to develop these metabolites and study their activity in order to directly provide these compounds without having to wait for metabolic reactions.

Note: Curcuminoids is the group of compounds that impart a orange yellow color to the spice. They also possess medicinal properties.

curcumin-vs-curcuminoids

What is curcumin?

Curcumin is the principal bioactive ingredient of turmeric. It is the most important and abundant curcuminoid. Curcumin comprises 2-5% of the rhizome content.

The chemical name of curcumin, is (1E, 6E) -1,7-bis(4-hydroxy-3-methoxyphenyl)- 1,6-heptadiene-3,5-dione and it is often referred to as diferruloylmethane.

Curcumin is a powerful antioxidant. It raises the level of antioxidant enzymes and scavenges reactive oxygen species. Dietary intake of such plant derived antioxidants is considered important since it protects the body from damage by reactive oxygen species.

Its anti-inflammatory property is assumed to be linked with its antioxidant property. It inhibits the activity of enzymes and chemicals that are produced during inflammation.

Apart from these principal features, curcumin is considered as a highly pleiotropic molecule and this still remains a mystery as to how one molecule exhibit so many features and target so many biological molecules.

For example it acts as a radiosensitizer and chemosensitizer to tumor cells and at the same time protect normal cells from side effects of such treatments. As an anti-microbial agent, it inhibits the growth of fungi, bacteria, viruses etc.

Some properties of curcumin are exclusive; for example its antidepressant activity, protection against cardiovascular diseases, action against cystic fibrosis, drug induced liver injury.Other curcuminoids may show these properties but their therapeutic effect would be weak.

Among all the curcuminoids, curcumin is the most potent one but the only drawback it faces is that it is not absorbed well in the body.

Note: Curcumin is the most important curcuminoid. It is the bioactive ingredient of turmeric and demonstrates a number of pharmacological properties.

So why are the terms ‘curcumin’ and curcuminoids’ used interchangeably?

Researchers clearly differentiate between curcumin and curcuminoids but the pharma industry for simplicity sake calls all curcuminoids as curcumin.

When opting for turmeric supplements it is  always recommend standardized 95% curcumin or curcuminoids.

This does not mean that 95% of the product is curcumin but rather 95% of the product contains curcuminoids. This further contains 70-80% of curcumin and the rest accounts for bisdemethoxycurcumin and demethoxycurcumin.

Why not 100% or just pure curcumin? Because it is not going to add to the potency or bioavailability but just add to extraction expenses.

A number of different formulations are made in order to make the curcuminoids more bioavailable. This table gives you a rough idea of the curcuminoid concentration present in the supplements.

Name

Contents

Bioavailability

Standardized 95% curcumin C95 95% curcuminoid mixture
Micronized Curcuminoids with turmeric oil 95% curcuminoid mixture plus turmeric oil 5 times greater than C95
Curcuminoid phospholipid complex 18-20%curcuminoids 40% phosphatidylcholine 30 times better than curcuminoids and 20 times better than curcumin
Curcuminoid cyclodextrin complex 2:1 cyclodextrin curcuminoid complex 14% curcuminoids 45 times better absorption than C95
Lipid curcumin particles 20-30% total curcuminoids, lipids and other inert materials 65 fold better absorption than free curcumin
Dispersed nanoparticle curcumin 10%curcumin, 2% other curcuminoids, glycerine, gum ghatti, water 27 times better than free curcumin
Hydrophilic carrier dispersed curcuminoids 20% curcuminoids, water soluble carriers and fat 45.9 more bioavailable than curcumin

Despite of reduction of curcuminoid concentration in the newer formulations the additional components increase the absorption of curcumin and other curcuminoids and this is better than absorption of older formulations of curcuminoids.

Conclusion

I hope this article has cleared the confusion of curcumin and curcuminoids.

Curcuminoids are a group of compounds that impart the golden yellow pigment to Curcuma species and curcumin is the most important curcuminoid.

For convenience sake manufacturers use the terms interchangeably but from the scientific point of view they are not the same. Any supplement stating that it has 95% standardized curcumin intends to say that 95% of the composition is curcuminoid mixture.

Save

Save

Post a Comment

Your email address will not be published. Required fields are marked *

*

14 Comments

  1. Very interesting and informative. I am using turmeric powder for quite some time. You mentioned that its color is golden yellow but in my country the powder is dark brown colored. Does this indicate that it is old stock or there are some other defects. If it is harmful then should I stop using it ? Will be thankful for your guidance.

  2. In ny view, the problem with the curcumin vs. curcuminoids conversation is that it loses sight of the fact that whole turmeric root contains an unbeatable synergy of curcumin, curcuminoids, essential oils and hundreds of other beneficial, bioactive compounds. The whole is greater than the sum of its parts. Super concentrating one or a few parts of turmeric, such as curcumin,, operates with the mistaken view that if some is good, more is better. Not true: 2 Tylenol cures headache, 200 kills you from liver falure. Supplement companies promote extracted products based on increased bioavailability, etc but the reality is that these products can be patented, whereas whole turmeric cannot, so it’s in their financial interest to do so. Incorporating turmeric in the diet is the best choice, but if not possible, choose an organic, whole turmeric powder supplement.

      1. I am taking turmeric powder of one table spoon with one pinch of black pepper with warm water of 200 Ml. is it OK or any problem-pls reply

        1. Hi. That is absolutely fine. Though we would advise taking it right after a meal so that food an dietary fat aids in absorption. You can take Golden Paste. Start with small doses such as 1/4-1/2 tsp and if you see no side effects then increase the dose gradually to 1 tsp 2-3 times a day over a few weeks. Best taken with food to avoid acid reflux. Avoid taking it at the same time when you take meds.
          http://www.turmericforhealth.com/turmeric-recipes/how-to-make-turmeric-paste-or-golden-paste
          http://www.turmericforhealth.com/turmeric-recipes/how-to-make-golden-paste-from-raw-fresh-turmeric

    1. Black pepper will increase potency of turmeric and absorption can be only increased by coconut oil or ghee,olive oil (fats)
      and such mixed paste should be taken with a meal .. easy way of doing it … I grow wild verity of turmeric in remote area of Kerala for cancer patients diet research …so we do follow latest developments in struggle to keep turmeric as a whole plant ..not divided and then promoted separated …

  3. So is this chart based on the same dosage for each product? For example, let’s assume for a moment that C95 is 1 gram. Is the same dosage (1 gram) apply to each product listed? So 1 gram of Micronized Curcuminoids with turmeric oil 5x greater than C95… 1 gram of Lipid curcumin particles 65x greater than C95.

    Some products are compared with “free cucumin”. How is the different from C95?

    1. The chart is based on the serum concentrations of curcumin after taking each formulation based on equal concentrations of curcumin in each formulation. The curcumin content in different formulations is kept the same say 1 g but the whole capsule may have a different weight.
      We will be covering this in detail in another article. And free curcumin same as C95 or standardized 95% curcumin extract.

  4. It is true taht curcumin does not mix well with water but melts in oil. Therefore, would it not be more efficacious to simply dissolve curcumin in a warm olive oil base to maximize absorption?

    1. Ye curcumin is poorly soluble in water but it is fat soluble. Heating curcumin in water increases its solubility by 9-12 folds. Yes curcumin in warm olive oil will increase the absorption. If you are taking supplements consuming it after the meal would help since dietary fat would take care of the absorption.