Can You Safely Take Turmeric / Curcumin with Xarelto?

Dietary consumption of turmeric is safe with Xarelto, but turmeric in high doses is not recommended along with regular Xarelto therapy. Since turmeric has anti-platelet activity, large amounts of turmeric or turmeric/curcumin supplements should be avoided as it may aggravate the blood thinning effects of the drug.

It is important that you please consult a health practitioner before taking turmeric/curcumin supplements or turmeric powder in large quantities along with Xarelto.

Can you Take Turmeric with Xarelto

Can You Safely Take Turmeric Curcumin with Xarelto

As per available studies, turmeric consumption with Xarelto may be of concern in two ways.

1. It may elevate the blood-thinning effect of the drug

Xarelto or rivaroxaban, is a blood-thinning medicine used to prevent the coagulation of blood and the formation of blood clots. It is commonly used for treating thrombosis and related disorders. It works by inhibiting the enzyme Factor Xa responsible for bringing about coagulation. [1] [2]

Turmeric and its active compound curcumin are known for their cardioprotective properties.

Read: Turmeric benefits to Heart

They are strong anticoagulants, due to which they have proved to be beneficial in treating disorders like deep vein thrombosis, stroke and arterial fibrillation. [3] [4] [5]

Studies have shown that turmeric has the same mechanism of action as Xarelto. Turmeric also carries out its blood-thinning effects by suppressing the same enzyme Factor Xa. [6][7]

As both Xarelto and turmeric have similar action, taking them together may increase the therapeutic activity.

Studies have shown the possible interaction of turmeric with anti-coagulants and antiplatelet agents. This interaction is synergistic in nature, which means that combined, they have an increased effect. [8]

However, this may also aggravate the side effects of Xarelto in some individuals which include severe internal bleeding or bleeding in the gastrointestinal tract.

If one is planning on taking turmeric or curcumin supplements for a particular health condition, together with Xarelto, it is recommended to consult a healthcare practitioner. This will help in preventing any unwanted effects on health.

2. Turmeric may affect metabolism of Xarelto in the body

Turmeric has low bioavailability due to which it is often used with black pepper in the golden paste.

Read: How to increase absorption of turmeric?

The active component of black pepper, piperine is a bioenhancer and increases absorption of turmeric, curcumin and also some drugs.[9] [10]

Thus, it is essential to consider the effect of piperine, turmeric and curcumin on drug pharmacokinetics.

Preliminary studies have hinted at the fact that Curcumin from turmeric and Piperine in black pepper can affect the process of drug metabolism and absorption.

Curcumin and piperine inhibit enzyme Cytochrome P450 3A4 and P-glycoprotein, both of which play a vital role in drug metabolism. [11] [12] [13]

Moreover, the drug Xarelto is a substrate of CYP3A4 and P-glycoprotein and is metabolised by these enzymes. Hence, according to scientists, it should not be used concomitantly with substances that inhibit both these proteins.[14]

Based on these studies, it can be said that turmeric may lower drug metabolism which further reduces the therapeutic action. It also makes the drug remain in the body for an extended period which may result in increased side effects, if any.

However, these are laboratory results, and there is very low possibility of occurrence of the same effect in humans. Also, further research and more extensive trials are required to ascertain these facts in human patients.[15]

Bottomline

It is clear that problems when taking turmeric alongside Xarelto may happen when either supplement are taken or a large amount of powder. Dietary intake (as a spice) of turmeric is safe with the drug as it contains curcumin in low amounts, which is unlikely to have significant effects.

While taking turmeric it is advised to maintain a gap of 3-4 hours to avoid possible interaction. Taking the drug 3-4 hours before taking turmeric will ensure that most of the drug is already metabolised before the inhibitory action of turmeric takes place.

Despite providing these precautionary measures, we strongly advise consulting a suitable health practitioner before taking turmeric/curcumin supplements with any blood thinning medicines including Xarelto.

If you are blood thinning medications and have taken turmeric along with it, do share your feedback to help others.

About the Author

TurmericForHealthTeam

Turmeric for Health's writer team consists of passionate writers from the fields of biotechnology, pharmacy, nutrition, Ayurveda & microbiology.Our writers are highly qualified with many having Ph.D., M.Tech & MSc degrees while others having B.Tech, BSc, B.Pharm. Our differentiation lies in researching and presenting ONLY FACTUAL SCIENTIFIC information. We spend 10s of hours to write a single article. Info of our articles is sourced from reliable scientific sources which are also provided as a link alongside for readers to refer if they want. You can read more about our team in the " About us" section.

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2 Comments

  1. I take vitamin k with tumeric. Since Vitamin k is a natural anticoagulant, is it also not advised as with Xarelto to take in combination with turmeric?

    1. I have been taking both! omg…I hope I don’t die. I’m taking 20mg of Xarelto, and 500mg of Turmeric, I think. whatever comes in the bottle. After my grandma pass from been told to stop taking blood thinning medication, 2 PEs, an uncle that died already from a PE, and having a gene mutation or blood disorder, I figured to start again. I have been feeling a pain on the lower right side and then now it has moved to under my rib cage. I think is a clot that I had there back in January… hopefully taking these two would watered it down enough not to kill me. We shall see, I should make an appointment with my doctor. 🙁 By the way I have to take blood thinners for life. So that’s why I wanted to try Turmeric, just so that I don’t have to spend $4,800 if I live to another 40 years.