Ankylosing spondylitis is arthritis that majorly affects the spine.
It comes under a group of diseases called seronegative spondyloarthropathies. These cause inflammation in joints and spine.
Ankylosing spondylitis causes inflammation of the sacroiliac joint where the spine joins the pelvis or hip bone. The bones of the spine may grow and fuse together leading to a stiff spine and stooped over posture.
Symptoms include constant pain and stiffness in the low back, the fusion of spine that may spread to hips, neck, backs or ribs and pain and inflammation in ligaments and tendons
. Chronic pain can lead to fatigue, fever, and loss of appetite.
Ankylosing spondylitis may affect other joints such as hip, knee, shoulder, and feet. It can affect other organs such as eyes, intestine, heart, and lungs.
Causative factors of ankylosing spondylitis are unknown but individuals with gene HLA-B27 tend to develop ankylosing spondylitis.
Ankylosing spondylitis typically begins in adolescents and young adults but affects people for the rest of their lives.
Men are more likely to develop ankylosing spondylitis than are women.
Treatment is generally focussed on reducing pain and stiffness. Medications prescribed include:
- Non-steroidal anti-inflammatory drugs: Such as ibuprofen and diclofenac to reduce pain and inflammation
- Opioid painkillers: To reduce pain
- Disease-modifying anti-rheumatic drugs: To treat arthritis of the spine
- Tumor necrosis factor alpha blockers and Anti-Interleukin 6 inhibitors: to inhibit and reduce production of inflammatory chemicals
Physical therapy and healthy diet also benefit in ankylosing spondylitis. In rare cases, surgery is recommended.
Table of Contents
- How can turmeric help in ankylosing spondylitis?
How can turmeric help in ankylosing spondylitis?
Turmeric is a potent anti-inflammatory and analgesic agent and these properties can benefit in the treatment of ankylosing spondylitis.
1. It is an anti-inflammatory agent
- Inhibiting the activity of various biochemical pathways involved in inflammation
- Reducing the production of inflammatory enzymes and proteins
- Preventing migration of inflammatory cells at the site of inflammation
- Inhibiting the activity of major proteins involved in inflammation like Tumor necrosis factor-alpha and nuclear factor kappa B
Aggarwal et. al have listed 30 molecular targets that curcumin modulates in order to bring about its anti-inflammatory effect.
A review of 6 clinical trials demonstrates that curcumin exerts a potent anti-inflammatory effect and inhibits the activity of inflammatory mediators such as interleukin, COX enzyme, prostaglandins, TNF, thromboxane, etc.
Doses up to 8g of curcumin are found to be safe.
What does this mean?
The prime reason why curcumin can benefit in ankylosing spondylitis is that it is an anti-inflammatory agent and can help reduce inflammation, pain and stiffness in this condition.
2. It reduces pain and protects the bone
Animal study shows that curcumin’s painkiller activity is comparable to that of nonsteroidal anti-inflammatory drug, diclofenac. Similarly curcumin is as effective as aspirin in reducing pain and swelling.
Sahebkar et. al conducted a review of 8 clinical trials that assessed the efficacy of curcuminoids as analgesic or painkillers. Curcuminoids significantly reduce pain and are found to be well tolerated.
Curcumin has beneficial effects on the skeletal system. Studies focussed on the effect of curcumin on damage and pain in intervertebral disc degeneration, which is characterized by chronic low back, demonstrate that curcumin exerts anti-inflammatory and analgesic property.
Curcumin inhibits the activity of inflammatory chemicals such as interleukin and tumor necrosis factor alpha and nuclear factor kappa B which aids in inhibiting inflammation.
Curcumin inhibits proliferation and mineralization of such cells. This could be of relevance when ankylosing spondilitis leads to the growth of bones in the spine and their fusion.
What does this mean?
Curcumin possess painkiller activity which can aid in reducing pain and stiffness in ankylosing spondylitis. It also has bone protective properties and may prevent bone cells from fusing in the spine. However adequate research is required to prove this point.
3. It is as effective as painkillers
Interestingly curcumin treated group showed significant improvement than patients in the diclofenac group and no adverse effects were reported.
Methotrexate is an anti-rheumatic drug that is prescribed in the treatment of ankylosing spondylitis. Research suggests that a combination of curcumin and methotrexate has a stronger anti-arthritic effect and curcumin reduces methotrexate induced liver damage.
Tumor necrosis factor-alpha is a protein that mediates inflammation. Infliximab, is a TNF blocker that is prescribed in the treatment of ankylosing spondylitis. Aggarwal et. al suggest that curcumin is a natural TNF-blocker and does not cause any side effects.
What does this mean?
Curcumin acts in the same way as most of the drugs prescribed in treatment of ankylosing spondylitis. Studies suggest that it potentiates the painkiller and anti-inflammatory activity when taken in combination with the respective drugs and also protects from the side effects of these drugs.
4.It serves to be therapeutic in autoimmune conditions and arthritis
Ankylosing spondylitis is autoimmune arthritis of the spine. Curcumin benefits in autoimmune conditions as it has an immunomodulating effect. It prevents the occurrence of unfavorable immune reactions.
Though not investigated in relation to ankylosing spondylitis, curcumin is found to be therapeutic in various forms of arthritis.
500mg of curcumin supplementation is found to significantly reduce pain, tenderness, and swelling in patients suffering from rheumatoid arthritis.
In fact, curcumin’s anti-arthritic and analgesic activity is found to be better than that of painkiller, diclofenac sodium.
In a clinical trial, a bioavailable formulation of curcumin was tested for its efficacy in knee osteoarthritis for 8 weeks. After 8 weeks, the pain was significantly less in curcumin treated group and it also lowered the dependence on an anti-arthritic drug, celecoxib.
What does this mean?
Curcumin helps treat autoimmune conditions and exhibits anti-arthritic effect in various arthritic conditions like rheumatoid arthritis and osteoarthritis.
5. It can aid in the treatment of ankylosing spondylitis complications
As mentioned earlier, the inflammation in ankylosing spondylitis can affect other organs. Uveitis is the inflammation of eye tissue and is a complication associated with ankylosing spondylitis.
Meriva was well tolerated and reduced eye discomfort and symptoms in more than 80% of the patients.
Another study reports that curcumin is as effective as steroids in treating uveitis and also does not cause side effects.
The inflammation can also spread to the heart and lungs.
Curcumin is a cardioprotective agent and can protect the heart from inflammation. It also offers protection from acute and chronic lung diseases and can work as an anti-inflammatory agent to suppress inflammation from spreading to lungs.
What does this mean?
Curcumin’s potent anti-inflammatory action can aid in preventing the inflammation to other parts of the body such as eyes, heart and lung and protect their function.
An effective way of taking turmeric that we recommend is The Golden Paste. The Golden Paste combines, turmeric, black pepper and oil which increase its absorption in the body thus leading to increased therapeutic efficacy. 1-2 teaspoons once or twice a day is helpful.
You can also include turmeric in your diet by adding it to your soups, smoothies or rice preparations. Its a great spice so you can use small to moderate amounts of it in the diet.
Turmeric in the diet is absolutely safe. If taken in excess, turmeric may cause gastric discomfort.
Turmeric supplements should be avoided in case of pregnancy and lactation. Turmeric may mildly increase bleeding risk and hence should be discontinued 2 weeks prior to surgery.
If suffering from gall bladder issues, do not take turmeric supplements. Turmeric supplements could have possible drug interactions with diabetes medication, blood thinning medications, stomach acid lowering medicines and certain antidepressants.
Please consult a doctor before taking turmeric supplements to ascertain right dose.
Turmeric, by virtue of it’s anti-inflammatory and analgesic property, can serve to be a complementary therapy in ankylosing spondylitis. Dietary turmeric can help in relieving pain and inflammation in ankylosing spondylitis and contribute to overall health improvement.